Web sites:
The Centre for Applied Genomics
The Chromosome 7 Project
Database of Genomic Variants

News:
Press Releases and Articles
Lay Reviews/Opinions/Editorials
Media/Scientific News Articles
Interviews
Dr. Scherer's Innovation Profile - TRRA - IGLOO

Contact Info:
Stephen W. Scherer
The Centre for Applied Genomics
The Hospital for Sick Children
14th Floor, Toronto Medical Discovery Tower/MaRS Discovery District
101 College St., Toronto, Ontario, M5G 1L7, Canada
(416) 813-7613 (office)
(416) 813-8319 (fax)

Jenny Kaderali,
Dr. Scherer's Assistant
Phone: (416) 813-7654 x1574     Fax: (416) 813-8319

23. Scherer, S.W., Duvoisin, R.M., Kuhn, R., Heng, H.H.Q., Belloni, E. and Tsui, L.-C. 1996. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. Genomics 31, 230-233. [PMID: 8824806]
24. Schanen, N.C., Scherer, S.W., Tsui, L.-C. and Francke, U. 1996. Assignment of the 5-hydroxytryptamine (serotonin) receptor 5A (HTR5A) gene to human chromosome band 7q36.1. Cytogenetics and Cell Genetics 72, 187-188. [PMID: 8978771]
25. Takahara, K., Osborne, L., Elliot, R.W., Tsui, L.-C., Scherer, S.W., and Greenspan, D.S. 1996. Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. Genomics 31, 253-256. [PMID: 8824813]
26. Tosi, S., Harbott, J., Haas, O.A., Douglas, A., Hughes, D.M., Ross, F., Biondi, A., Scherer, S.W. and Kearney, L. 1996. Classification of deletions and identification of cryptic translocations involving 7q by fluorescence in situ hybridization (FISH). Leukemia 10, 644-649. [PMID: 8618441]
27. Hoglund, P., Haila, S., Scherer, S.W., Tsui, L.C., Green, E.D., Weissenbach, J., Holmberg, C., de la Chapelle, A. and Kere, J. 1996. Positional candidate genes for congenital chloride diarrhea suggested by high-resolution physical mapping in chromosome 7q31. Genome Research 6, 202-210. [PMID: 8963897]
28. Crackower, M.A.*, Scherer, S.W.*, Rommens, J.M., Hui, C.C., Poorkaj, P., Soder, S., Cobben, J.M., Hudgins, L., Evans, J.P. and Tsui, L.-C. 1996. Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. Human Molecular Genetics 5, 571-579. *contributed equally to the manuscript. [PMID: 8733122]
29. Ignatius, J., Knuutila, S., Scherer, S.W., Trask, B. and Kere, J. 1996. Split hand/split foot malformation, deafness, and mental retardation with a complex cytogenetic rearrangement involving 7q21.3. Journal of Medical Genetics 33, 507-510. [PMID: 8782053]
30. Johnson, E.J., Scherer, S.W., Osborne, L., Tsui, L.-C., Oscier, D., Mould, S. and Cotter, F. 1996. Molecular definition of a narrow interval at 7q22.1 associated with myelodysplasia. Blood 87, 3579-3586. [PMID: 8611680]
31. Scherer, S.W., Feinstein, D., Oliveira, L., Tsui, L.-C. and Pittler, S.J. 1996. Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1). Genomics 35, 241-243. [PMID: 8661128]
32. Lin, J.C., Scherer, S.W., Tougas, L., Traverso, G., Tsui, L.-C., Andrulis, I., Jothy, S. and Park, M. 1996. Detailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET. Oncogene 13, 2001-2008. [PMID: 8934547]
33. Molnar, A., Wu, P., Largespada, D., Vortkamp, A., Scherer, S.W., Copeland, N.G., Jenkins, N.A., Bruns, G. and Georgeopoulos, K. 1996. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. Journal of Immunology 156, 585-592. [PMID: 8543809]
34. Rowles, J.C., Scherer, S.W., Xi, T., Majer, M., Nickle, D.C., Rommens, J., Popov, K., Harris, R.A., Riebow, N.L., Xia, J., Tsui, L.-C., Bogardus, C. and Prochazka, M. 1996. Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. Journal of Biological Chemistry 271, 22376-22382. [PMID: 8798399]
35. Osborne, L.R., Martindale, D., Scherer, S.W., Shi, X.-M., Huizenga, J., Heng, H.H.Q., Costa, T., Pober, B., Lew, L., Brinkman, J., Rommens, J.M., Koop, B. and Tsui, L.-C. 1996. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome. Genomics 36, 328-336. [PMID: 8812460]
36. Rozman, D., Stromsted, M., Tsui, L.-C., Scherer, S.W. and Waterman, M.R. 1996. Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Genomics 38, 371-381. [PMID: 8975714]
37. Eppert, K., Scherer, S.W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L.-C., Bapat, B., Gallinger, S., Andrulis, I.L., Thomsen, G.H., Wrana, J.L. and Attisano, L. 1996. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86, 543-552. [PMID: 8752209]
38. Mackay, M., Fantes, J., Scherer, S.W., Boyle, S., West, K., Tsui, L.-C., Belloni, E., Lutz, E., Van Heyningen, V. and Harmar, A.J. 1996. Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype. Genomics 37, 345-353. [PMID: 8938447]
39. Belloni, E., Muenke, M., Roessler, E., Traverso, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H.F., Donis-Keller, H., Helms, C., Hing, A.V., Heng, H.H.Q., Koop, B., Martindale, D., Rommens, J.M., Tsui, L.-C. and Scherer, S.W. 1996. Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nature Genetics 14, 353-356. [PMID: 8896571]
40. Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S.W., Tsui, L.-C. and Muenke, M. 1996. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nature Genetics 14, 357-360. [PMID: 8896572]
41. Gaedigk, R., Karges, W., Hui, M.F., Scherer, S.W. and Dosch, H-M. 1996. Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity. Genomics 38, 382-391. [PMID: 8975715]
42. Nakabayashi, K., Ogata, T., Fujii, M., Takahashi, E., Ogino, H., Michishita, E., Scherer, S.W., Tsui, L.-C. and Ayusawa, D. 1996. A panel of radiation hybrids defining the 7q31-q32 region of human chromosome 7. DNA Research 3, 181-183. [PMID: 8905237]